I tried compressing to OGG vobis, which resulted in a crashing game even before the intro. It's not more complicated, but it took more time.

And I read that compressing the .san files makes the stuttering even worse, so I refrained from doing so. Can anyone confirm this?

After a couple of hours trying different things, I finally got The Curse of Monkey Island running perfectly fine on the Wii. If you're experiencing hiccups, looong loading times and off lip-syncing, this might help: PREPARATION 1. Get the latest ScummVM, atm this is rev32565: 2. Usa a Fat(16)-format...